JPH0245640B2 - - Google Patents

Info

Publication number
JPH0245640B2
JPH0245640B2 JP57001378A JP137882A JPH0245640B2 JP H0245640 B2 JPH0245640 B2 JP H0245640B2 JP 57001378 A JP57001378 A JP 57001378A JP 137882 A JP137882 A JP 137882A JP H0245640 B2 JPH0245640 B2 JP H0245640B2
Authority
JP
Japan
Prior art keywords
asparagine
formula
phenylbutanoyl
hydroxy
bestatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57001378A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58121259A (ja
Inventor
Hamao Umezawa
Tomio Takeuchi
Takaaki Aoyanagi
Kenji Kawamura
Shunzo Fukatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP57001378A priority Critical patent/JPS58121259A/ja
Priority to US06/439,821 priority patent/US4473554A/en
Priority to EP83100062A priority patent/EP0083931A3/en
Publication of JPS58121259A publication Critical patent/JPS58121259A/ja
Publication of JPH0245640B2 publication Critical patent/JPH0245640B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP57001378A 1982-01-09 1982-01-09 ベスタチン新規誘導体 Granted JPS58121259A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP57001378A JPS58121259A (ja) 1982-01-09 1982-01-09 ベスタチン新規誘導体
US06/439,821 US4473554A (en) 1982-01-09 1982-11-08 Bestatin-related compounds as immunopotentiator
EP83100062A EP0083931A3 (en) 1982-01-09 1983-01-05 New bestatin-related compounds as immunopotentiator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57001378A JPS58121259A (ja) 1982-01-09 1982-01-09 ベスタチン新規誘導体

Publications (2)

Publication Number Publication Date
JPS58121259A JPS58121259A (ja) 1983-07-19
JPH0245640B2 true JPH0245640B2 (en]) 1990-10-11

Family

ID=11499816

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57001378A Granted JPS58121259A (ja) 1982-01-09 1982-01-09 ベスタチン新規誘導体

Country Status (3)

Country Link
US (1) US4473554A (en])
EP (1) EP0083931A3 (en])
JP (1) JPS58121259A (en])

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE78696T1 (de) * 1987-12-30 1992-08-15 Vsesojuznyj Kardiologitsches Arzneimittelzubereitung zur behandlung des immunmangels.
US5814611A (en) * 1988-12-14 1998-09-29 Cytoven J.V. Pharmaceutical for the therapy of immune deficiency conditions
US6136788A (en) * 1987-12-30 2000-10-24 Cytran, Inc. Pharmaceutical preparation for the therapy of immune deficiency conditions
IT1216103B (it) * 1988-03-16 1990-02-22 Zambon Spa Peptidi ad attivita' farmaceutica.
CN112125951A (zh) * 2020-10-22 2020-12-25 深圳万乐药业有限公司 一种乌苯美司原料药中的杂质及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052449A (en) * 1974-07-01 1977-10-04 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Biologically active substance, bestatin, and production thereof
US4189604A (en) * 1975-07-22 1980-02-19 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Bestatin
JPS6026099B2 (ja) * 1977-09-21 1985-06-21 財団法人微生物化学研究会 ペプチド、その酸附加塩およびその製造法
US4370318A (en) * 1980-07-07 1983-01-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Bestatin-related compounds as immunopotentiator
JPS5767516A (en) * 1980-09-24 1982-04-24 Microbial Chem Res Found Novel analgesic agent
JPS6014040A (ja) * 1983-07-06 1985-01-24 Hitachi Ltd 熱源機の運転方法

Also Published As

Publication number Publication date
EP0083931A2 (en) 1983-07-20
EP0083931A3 (en) 1984-05-02
US4473554A (en) 1984-09-25
JPS58121259A (ja) 1983-07-19

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